Modulation of osteogenic differentiation in human skeletal cells in Vitro by 5-azacytidine.
Cellular differentiation is controlled by a variety of factors including gene methylation, which represses particular genes as cell fate is determined. The incorporation of 5-azacytidine (5azaC) into DNA in vitro prevents methylation and thus can alter cellular differentiation pathways. Human bone m...
Main Authors: | Locklin, R, Oreffo, R, Triffitt, J |
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Format: | Journal article |
Language: | English |
Published: |
1998
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