Tetrahydrobiopterin availability directly regulates eNOS coupling in tet-regulatable cells

Tetrahydrobiopterin availability directly regulates eNOS coupling in tet-regulatable cells

Manylion Llyfryddiaeth
Prif Awduron:	Crabtree, M, Al-Wakeel, Y, Warrick, N, de Bono, J, Cai, S, Tatham, A, Channon, K, Alp, N
Fformat:	Conference item
Cyhoeddwyd:	2007

Eitemau Tebyg

Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.
gan: Crabtree, M, et al.
Cyhoeddwyd: (2009)

Tetrahydrobiopterin- and glutathionylation-dependent regulation of eNOS coupling: Relationships revealed by eNOS glutathionylation mutants in cells with tet-regulated GTP cyclohydrolase I expression
gan: Crabtree, M, et al.
Cyhoeddwyd: (2012)

Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression.
gan: Bendall, J, et al.
Cyhoeddwyd: (2005)

Tetrahydrobiopterin-dependent eNOS coupling determines vascular remodeling through accelerated endothelial regeneration
gan: Ali, Z, et al.
Cyhoeddwyd: (2007)

Tetrahydrobiopterin-dependent eNOS coupling mediates endothelial regeneration and attenuates vein graft atherosclerosis in ApoE-KO mice
gan: Ali, Z, et al.
Cyhoeddwyd: (2007)

Endothelial-targeted GTP cyclohydrolase I overexpression increases endothelial tetrahydrobiopterin levels and preserves eNOS coupling in eNOS overexpressing mice
gan: Bendall, J, et al.
Cyhoeddwyd: (2004)

Intravenous infusion of 5-methyl-tetrahydrofolate rapidly improves eNOS Coupling. In human vessels by increasing tetrahydrobiopterin bioavailability
gan: Antoniades, C, et al.
Cyhoeddwyd: (2006)

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
gan: Cai, S, et al.
Cyhoeddwyd: (2005)

Regulation of eNOS function by tetrahydrobiopterin in vascular disease
gan: Channon, K
Cyhoeddwyd: (2004)

Endothelial tetrahydrobiopterin (BH4) regulates eNOS coupling in vivo: Functional effects of BH4-eNOS stoichiometry in endothelial targeted transgenic mice
gan: Bendall, J, et al.
Cyhoeddwyd: (2005)

Regulation of endothelial nitric oxide synthase (eNOS) by tetrahydrobiopterin in vascular disease
gan: Alp, N, et al.
Cyhoeddwyd: (2004)

5-methyl-tetrahydrofolate increases eNOS activity by preventing peroxynitrite-induced oxidation of tetrahydrobiopterin in human vessels
gan: Antoniades, C, et al.
Cyhoeddwyd: (2006)

GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression.
gan: Tatham, A, et al.
Cyhoeddwyd: (2009)

Endothelial tetrahydrobiopterin regulates eNOS coupling/uncoupling independent of vascular disease: Insights from targeted transgenic models
gan: Bendall, J, et al.
Cyhoeddwyd: (2004)

A pivotal role for tryptophan 447 in enzymatic coupling of human endothelial nitric oxide synthase (eNOS): effects on tetrahydrobiopterin-dependent catalysis and eNOS dimerization.
gan: Benson, M, et al.
Cyhoeddwyd: (2013)

5-Methyl-tetrahydrofolate acid improves endothelial function and decreases superoxide production by improving eNOS coupling and increasing tetrahydrobiopterin bioavailability in human vessels in vivo
gan: Antoniades, C, et al.
Cyhoeddwyd: (2006)

Tetrahydrobiopterin-dependent eNOS coupling attenuates vein graft atherosclerosis through inhibition of MCP-1 mediated monocyte recruitment to sites of vascular injury
gan: Ali, Z, et al.
Cyhoeddwyd: (2007)

Increased eNOS coupling protects against vein graft accelerated atherosclerosis in ApoE-KO mice
gan: Ali, Z, et al.
Cyhoeddwyd: (2006)

Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways.
gan: Crabtree, M, et al.
Cyhoeddwyd: (2009)

5-methyl-tetrahydrofolic acid increases nitric oxide bioavailability and decreases superoxide production by improving eNOS coupling in human vessels in vivo: Effects on intracellular tetrahydrobiopterin oxidation
gan: Antoniades, C, et al.
Cyhoeddwyd: (2006)

Low- and high- dose treatment with folic acid, equally improve endothelial function and decrease superoxide production in human vessels via tetrahydrobiopterin-mediated eNOS coupling
gan: Antoniades, C, et al.
Cyhoeddwyd: (2007)

Relationships between nitric oxide-mediated endothelial function, eNOS coupling and blood pressure revealed by eNOS-GTP cyclohydrolase 1 double transgenic mice.
gan: Adlam, D, et al.
Cyhoeddwyd: (2007)

Rapid Effects of Atorvastatin on Tetrahydrobiopterin-Mediated eNOS Coupling in Human Arteries, is Mediated by Stimulation of Vascular GTP-Cyclohydrolase
gan: Antoniades, C, et al.
Cyhoeddwyd: (2011)

Oral Atorvastatin Treatment Improves NO Bioavailability and Vascular Redox State in the Human Arterial Wall, via a Tetrahydrobiopterin-Mediated Improvement of eNOS Coupling
gan: Antoniades, C, et al.
Cyhoeddwyd: (2011)

Increased endothelial tetrahydrobiopterin synthesis reduces vein graft accelerated atherosclerosis in apolipoprotein E-knockout mice
gan: Ali, Z, et al.
Cyhoeddwyd: (2006)

Conditional knockout of GCH1 in leukocytes and endothelial cells: A novel model to study tetrahydrobiopterin-dependent NOS functions in vivo
gan: McNeill, E, et al.
Cyhoeddwyd: (2012)

5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling.
gan: Antoniades, C, et al.
Cyhoeddwyd: (2006)

Increased endothelial tetrahydrobiopterin synthesis reduces vein graft atherosclerosis in ApoE-knockout mice
gan: Ali, Z, et al.
Cyhoeddwyd: (2005)

Chronic treatment with folic acid improves nitric oxide bioavailability and decreases superoxide production in human vessels, through tetrahydrobiopterin-mediated improvement of eNOS coupling
gan: Antoniades, C, et al.
Cyhoeddwyd: (2007)

BH4-dependent eNOS coupling in vascular disease pathogenesis
gan: Channon, K
Cyhoeddwyd: (2008)

PROTECTIVE EFFECTS OF TETRAHYDROBIOPTERIN IN ISCHEMIA REPERFUSION INJURY DO NOT DEPEND ON DIMERISATION STATUS OF ENOS
gan: Maglione, M, et al.
Cyhoeddwyd: (2013)

Increased endothelial tetrahydrobiopterin levels in GTPCH-transgenic mice
gan: Alp, N, et al.
Cyhoeddwyd: (2002)

A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in vascular resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice
gan: Chuaiphichai, S, et al.
Cyhoeddwyd: (2017)

Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation
gan: Carnicer, R, et al.
Cyhoeddwyd: (2012)

Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation
gan: Carnicer, R, et al.
Cyhoeddwyd: (2012)

5-Methyl-tetrahydrofolic acid rapidly improves endothelial function and superoxide production in human atherosclerosis: Effects on tetrahyd robiopterin-dependent eNOS coupling
gan: Antoniades, C, et al.
Cyhoeddwyd: (2006)

Correction of tetrahydrobiopterin deficiency - Implications for dopa responsive dystonia and other inherited disorders of tetrahydrobiopterin metabolism
gan: Heales, S, et al.
Cyhoeddwyd: (2005)

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
gan: Alp, N, et al.
Cyhoeddwyd: (2004)

Endothelial cell tetrahydrobiopterin: going with the flow.
gan: De Bono, J, et al.
Cyhoeddwyd: (2007)

Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS.
gan: Crabtree, M, et al.
Cyhoeddwyd: (2008)