Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes.

The action of repaglinide, a novel insulin secretagogue, was compared with the sulfonylurea glibenclamide with regard to the hypoglycemic action in vivo, binding to betaTC-3 cells, insulin secretion from perifused mouse islets, and capacity to stimulate exocytosis by direct interaction with the secr...

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Bibliographic Details
Main Authors: Fuhlendorff, J, Rorsman, P, Kofod, H, Brand, C, Rolin, B, MacKay, P, Shymko, R, Carr, R
Format: Journal article
Language:English
Published: 1998