Common and rare variants in multifactorial susceptibility to common diseases.
Here, we give a historical overview of the search for genetic variants that influence the susceptibility of an individual to a chronic disease, from RA Fisher's seminal work to the current excitement of whole-genome association studies (WGAS). We then discuss the concepts behind the identificat...
Autors principals: | Bodmer, W, Bonilla, C |
---|---|
Format: | Journal article |
Idioma: | English |
Publicat: |
2008
|
Ítems similars
-
Rare variant hypothesis for multifactorial inheritance: susceptibility to colorectal adenomas as a model.
per: Fearnhead, N, et al.
Publicat: (2005) -
A common mtDNA variant may be a susceptibility factor in 3 multifactorial diseases.
per: Poulton, J, et al.
Publicat: (2001) -
Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas.
per: Fearnhead, N, et al.
Publicat: (2004) -
Rare copy-number variants as modulators of common disease susceptibility
per: Chiara Auwerx, et al.
Publicat: (2024-01-01) -
Genetic susceptibility to multifactorial diseases.
per: Hill, A
Publicat: (1997)