Common and rare variants in multifactorial susceptibility to common diseases.

Common and rare variants in multifactorial susceptibility to common diseases.

Here, we give a historical overview of the search for genetic variants that influence the susceptibility of an individual to a chronic disease, from RA Fisher's seminal work to the current excitement of whole-genome association studies (WGAS). We then discuss the concepts behind the identificat...

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Bibliografiske detaljer
Main Authors:	Bodmer, W, Bonilla, C
Format:	Journal article
Sprog:	English
Udgivet:	2008

Lignende værker

Rare variant hypothesis for multifactorial inheritance: susceptibility to colorectal adenomas as a model.
af: Fearnhead, N, et al.
Udgivet: (2005)

A common mtDNA variant may be a susceptibility factor in 3 multifactorial diseases.
af: Poulton, J, et al.
Udgivet: (2001)

Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas.
af: Fearnhead, N, et al.
Udgivet: (2004)

Rare copy-number variants as modulators of common disease susceptibility
af: Chiara Auwerx, et al.
Udgivet: (2024-01-01)

Genetic susceptibility to multifactorial diseases.
af: Hill, A
Udgivet: (1997)

Common disease, multiple rare (and distant) variants.
af: Richard Robinson
Udgivet: (2010-01-01)

The HLA system and the analysis of multifactorial genetic disease.
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Udgivet: (1995)

Association of common genetic variant with susceptibility to invasive pneumococcal disease
af: Roy, S, et al.
Udgivet: (2002)

Identification of rare and common variants in BNIP3L: a schizophrenia susceptibility gene
af: Juan Zhou, et al.
Udgivet: (2020-05-01)

Common or rare variants for complex traits?
af: Munafò, MR, et al.
Udgivet: (2014)

Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates
af: Jae Hoon Sul, et al.
Udgivet: (2020-02-01)

The impact of rare and low-frequency genetic variants in common disease
af: Lorenzo Bomba, et al.
Udgivet: (2017-04-01)

Probability of Alzheimer’s disease based on common and rare genetic variants
af: Valentina Escott-Price, et al.
Udgivet: (2021-08-01)

Common disease: are causative alleles common or rare?
af: Robert Shields
Udgivet: (2011-01-01)

Investigating rare genetic variants in common migraine
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Udgivet: (2014)

A Rare Variant of a Common Nodule
af: Nancy Xi, et al.
Udgivet: (2020-08-01)

Research pointers: Association of common genetic variant with susceptibility to invasive pneumococcal disease.
af: Roy, S, et al.
Udgivet: (2002)

Correction to: Probability of Alzheimer’s disease based on common and rare genetic variants
af: Valentina Escott-Price, et al.
Udgivet: (2021-09-01)

The 'common disease-common variant' hypothesis and familial risks.
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Udgivet: (2008-01-01)

Common variants at 11p13 are associated with susceptibility to tuberculosis.
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Udgivet: (2012)

Common variants at 11p13 are associated with susceptibility to tuberculosis
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Udgivet: (2012)

Common Genetic Variants in Rare Disorders: Hematology and Beyond
af: Paschalis Evangelidis, et al.
Udgivet: (2025-01-01)

Examining the role of common and rare mitochondrial variants in schizophrenia.
af: Vanessa F Gonçalves, et al.
Udgivet: (2018-01-01)

Common variants at 19p13 are associated with susceptibility to ovarian cancer.
af: Bolton, K, et al.
Udgivet: (2010)

Genetic susceptibility to common mycobacterial diseases
af: Wong, H
Udgivet: (2010)

Susceptibility of Clinical Enterobacterales Isolates With Common and Rare Carbapenemases to Mecillinam
af: Frieder Fuchs, et al.
Udgivet: (2021-01-01)

Clear Cell Myeloma - A Rare Histopathological Variant of a Common Disease
af: Neha Agarwal, et al.
Udgivet: (2024-01-01)

Discovery of common and rare genetic risk variants for colorectal cancer
af: Huyghe, JR, et al.
Udgivet: (2018)

Common sequence variants affect molecular function more than rare variants?
af: Yannick Mahlich, et al.
Udgivet: (2017-05-01)

Differential confounding of rare and common variants in spatially structured populations
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Udgivet: (2012)

Differential confounding of rare and common variants in spatially structured populations.
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Udgivet: (2012)

Spectrum of Rare and Common Genetic Variants in Arrhythmogenic Cardiomyopathy Patients
af: Melania Lippi, et al.
Udgivet: (2022-07-01)

Rare and common variants analysis of the EMB gene in patients with schizophrenia
af: Juan Zhou, et al.
Udgivet: (2020-03-01)

On genetic variants underlying common disease
af: Hechter, E
Udgivet: (2011)

Hirschsprung disease: common and uncommon variants
af: Lily S Cheng, et al.
Udgivet: (2024-08-01)

A robust GWSS method to simultaneously detect rare and common variants for complex disease.
af: Chung-Feng Kao, et al.
Udgivet: (2015-01-01)

Common variants in the CYP2C19 gene are associated with susceptibility to endometriosis
af: Painter, J, et al.
Udgivet: (2014)

Common variants in the CYP2C19 gene are associated with susceptibility to endometriosis.
af: Painter, J, et al.
Udgivet: (2014)

Common risk variants for epilepsy are enriched in families previously targeted for rare monogenic variant discovery
af: Karen L. Oliver, et al.
Udgivet: (2022-07-01)

Targeted sequencing identifies novel variants in common and rare MODY genes
af: Lucas S. deSantana, et al.
Udgivet: (2019-12-01)