Common and rare variants in multifactorial susceptibility to common diseases.

Common and rare variants in multifactorial susceptibility to common diseases.

Here, we give a historical overview of the search for genetic variants that influence the susceptibility of an individual to a chronic disease, from RA Fisher's seminal work to the current excitement of whole-genome association studies (WGAS). We then discuss the concepts behind the identificat...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Bodmer, W, Bonilla, C
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	2008

Antzeko izenburuak

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Argitaratua: (2005)

A common mtDNA variant may be a susceptibility factor in 3 multifactorial diseases.
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Argitaratua: (2001)

Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas.
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Argitaratua: (2002)

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Argitaratua: (2020-05-01)

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Argitaratua: (2014)

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Common variants at 11p13 are associated with susceptibility to tuberculosis
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Common variants at 19p13 are associated with susceptibility to ovarian cancer.
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Argitaratua: (2021-01-01)

Clear Cell Myeloma - A Rare Histopathological Variant of a Common Disease
nork: Neha Agarwal, et al.
Argitaratua: (2024-01-01)

Discovery of common and rare genetic risk variants for colorectal cancer
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Argitaratua: (2018)

Common sequence variants affect molecular function more than rare variants?
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Argitaratua: (2012)

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Spectrum of Rare and Common Genetic Variants in Arrhythmogenic Cardiomyopathy Patients
nork: Melania Lippi, et al.
Argitaratua: (2022-07-01)

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nork: Juan Zhou, et al.
Argitaratua: (2020-03-01)

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Argitaratua: (2011)

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Argitaratua: (2024-08-01)

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nork: Chung-Feng Kao, et al.
Argitaratua: (2015-01-01)

Common variants in the CYP2C19 gene are associated with susceptibility to endometriosis
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Argitaratua: (2014)

Common variants in the CYP2C19 gene are associated with susceptibility to endometriosis.
nork: Painter, J, et al.
Argitaratua: (2014)

Common risk variants for epilepsy are enriched in families previously targeted for rare monogenic variant discovery
nork: Karen L. Oliver, et al.
Argitaratua: (2022-07-01)

Targeted sequencing identifies novel variants in common and rare MODY genes
nork: Lucas S. deSantana, et al.
Argitaratua: (2019-12-01)