Traceless rhodium-catalyzed hydroacylation using alkyl aldehydes: the enantioselective synthesis of β-aryl ketones
A one-pot three-step sequence involving Rh-catalyzed alkene hydroacylation, sulfide elimination and Rh-catalyzed aryl boronic acid conjugate addition, delivers products of traceless chelation-controlled hydroacylation employing alkyl aldehydes. The stereodefined β-aryl ketones are obtained in good y...
| Main Authors: | , , |
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| Format: | Journal article |
| Published: |
Wiley
2016
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| Summary: | A one-pot three-step sequence involving Rh-catalyzed alkene hydroacylation, sulfide elimination and Rh-catalyzed aryl boronic acid conjugate addition, delivers products of traceless chelation-controlled hydroacylation employing alkyl aldehydes. The stereodefined β-aryl ketones are obtained in good yields with excellent control of enantioselectivity. Good variation of all three reaction components is possible. |
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