Mouse knockout models for HIV-1 restriction factors.
Infection of cells with human immunodeficiency virus 1 (HIV-1) is controlled by restriction factors, host proteins that counteract a variety of steps in the life cycle of this lentivirus. These include SAMHD1, APOBEC3G and tetherin, which block reverse transcription, hypermutate viral DNA and preven...
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| Format: | Journal article |
| Language: | English |
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2014
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