Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant.

BACKGROUND: Obesity is highly associated with elevated serum triglycerides, hepatic steatosis and type 2 diabetes (T2D). The I148M (rs738409) genetic variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is known to modulate hepatic triglyceride accumulation, leading to steatosis....

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Bibliografische gegevens
Hoofdauteurs:	Palmer, C, Maglio, C, Pirazzi, C, Burza, M, Adiels, M, Burch, L, Donnelly, L, Colhoun, H, Doney, A, Dillon, J, Pearson, E, Mccarthy, M, Hattersley, A, Frayling, T, Morris, A, Peltonen, M, Svensson, P, Jacobson, P, Borén, J, Sjöström, L, Carlsson, L, Romeo, S
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	Public Library of Science 2012

Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant.

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