Forward genetic analysis of mammalian immunity

Forward genetic analysis of mammalian immunity

<p>Mutation, whether spontaneous or induced, is the premier tool for understanding gene function. One approach is to create mutations in a specific gene, and then use the resulting cell or organism to search for a phenotype. An alternative is to create mutations at random, and focus first on t...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Siggs, O, Owen Siggs
Awduron Eraill:	Beutler, B
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2012
Pynciau:	Immunology Genetics (life sciences)

Eitemau Tebyg

Dissecting mammalian immunity through mutation
gan: Siggs, O
Cyhoeddwyd: (2014)

Dissecting mammalian immunity through mutation.
gan: Siggs, O
Cyhoeddwyd: (2014)

Forward genetic and cellular studies of immune regulation: the roles of Carma1, Interleukin-10 and Gimap5
gan: Barnes, MJ
Cyhoeddwyd: (2010)

Genetics determinants of vaccine responses
gan: O'Connor, D
Cyhoeddwyd: (2014)

Investigation of expression quantitative trait loci and regulatory genetic variants in primary human immune cells
gan: Makino, S
Cyhoeddwyd: (2013)

NOVEL LYMPHOCYTE DEFICIENCIES REVEALED BY MOUSE FORWARD GENETICS
gan: Siggs, O, et al.
Cyhoeddwyd: (2012)

Impact of genetic variation on gene regulatory effects of vitamin D in immunity and inflammation
gan: Berlanga-Taylor, A
Cyhoeddwyd: (2013)

Genetic studies in ulcerative colitis
gan: Bryant, RV
Cyhoeddwyd: (2015)

Epigenetic regulation of the myeloid cell lineage
gan: Pliuskys, L
Cyhoeddwyd: (2014)

Analyses of functional sequence in mammalian and avian genomes
gan: Rands, C, et al.
Cyhoeddwyd: (2014)

Functional characterization of ankylosing spondylitis genetic risk variants
gan: Osgood, JA
Cyhoeddwyd: (2019)

Immunology : Mammalian watchdog targets bacteria
gan: Kundu, Parag, et al.
Cyhoeddwyd: (2015)

Functional characterisation of a multiple sclerosis-associated genetic variant
gan: Gregory, A
Cyhoeddwyd: (2012)

Immune Thrombocytopenia: Immune Dysregulation and Genetic Perturbations Deciphering the Fate of Platelets
gan: Zahra Tariq, et al.
Cyhoeddwyd: (2024-09-01)

Influence of genetic and environmental factors on the immunogenicity of Hib vaccine in Gambian twins
gan: Lee, Y, et al.
Cyhoeddwyd: (2006)

The role of DOCK8 in the maintenance of CD8+ T cell memory and invariant NKT cells
gan: Crawford, G
Cyhoeddwyd: (2012)

Mammalian BEX, WEX and GASP genes: Coding and non-coding chimaerism sustained by gene conversion events
gan: Winter, E, et al.
Cyhoeddwyd: (2005)

Genetically programmed alternative splicing of NEMO mediates an autoinflammatory disease phenotype
gan: Younglang Lee, et al.
Cyhoeddwyd: (2022-03-01)

Genetic association with autoimmune diseases identifies molecular mechanisms of coronary artery disease
gan: Sophia Kerns, et al.
Cyhoeddwyd: (2024-09-01)

Analysis of the CD200R family
gan: Akkaya, M
Cyhoeddwyd: (2011)

Translating non-coding genetic associations into a better understanding of immune-mediated disease
gan: Christina T. Stankey, et al.
Cyhoeddwyd: (2023-03-01)

Functional genomics of severe sepsis and septic shock
gan: Radhakrishnan, J
Cyhoeddwyd: (2013)

Construction and validation of Plasmodium antigens surface display library in mammalian cells.
gan: Tan, Li Hua.
Cyhoeddwyd: (2009)

Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice
gan: Okiru Komine, et al.
Cyhoeddwyd: (2024-02-01)

Allele specific gene expression in the major histocompatibility complex
gan: Plant, K
Cyhoeddwyd: (2012)

The functional consequences of autoimmune variants in the tyrosine kinase 2 gene region
gan: Shipman, L
Cyhoeddwyd: (2014)

CIITA promoter polymorphism impairs monocytes HLA-DR expression in patients with septic shock
gan: Jordi Miatello, et al.
Cyhoeddwyd: (2022-11-01)

Genetics of ankylosing spondylitis
gan: Karaderi, T
Cyhoeddwyd: (2012)

Genetic determinants of EBV infection in lymphoblastoid cell lines
gan: Czyz, W, et al.
Cyhoeddwyd: (2014)

An insight into osteoarthritis susceptibility: Integration of immunological and genetic background
gan: Debora Stefik, et al.
Cyhoeddwyd: (2021-04-01)

Analytic pipelines to assess the relationship between immune response and germline genetics in human tumors
gan: Rosalyn W. Sayaman, et al.
Cyhoeddwyd: (2022-12-01)

NKT cells promote Th1 immune bias to dengue virus that governs long-term protective antibody dynamics
gan: Choi, Youngjoo, et al.
Cyhoeddwyd: (2024)

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.
gan: Arnold, C, et al.
Cyhoeddwyd: (2012)

Branches and Key Components of Genetics /
gan: Linares, Marie, author 648628, et al.
Cyhoeddwyd: (2012)

Identification of the cellular and molecular mechanisms of IL-23 driven intestinal inflammation
gan: Schiering, C
Cyhoeddwyd: (2013)

The impact of genetic variation on IFITM3 related influenza virus restriction
gan: Laurenson-Schafer, H
Cyhoeddwyd: (2018)

Molecular genetics of mammalian cells/
gan: Gottesma, Michael M.
Cyhoeddwyd: (1987)

Unravelling the association of partial T-cell immunodeficiency and immune dysregulation.
gan: Liston, A, et al.
Cyhoeddwyd: (2008)

History, Research and Key Concepts of Genetics /
gan: Major, Jude, author 648645, et al.
Cyhoeddwyd: (2012)

Genetic signature detected in T cell receptors from patients with severe COVID-19
gan: Manuel Corpas, et al.
Cyhoeddwyd: (2023-10-01)