STEREOSPECIFIC AMINO-ACID SYNTHESIS - PREPARATION OF THE GAMMA-ANION DERIVED FROM GLUTAMIC-ACID

Reaction of α-t-butyl γ-methyl N-trityl-L-glutamate (7) with lithium isopropylcyclohexylamide in hexane leads to the specific formation of the γ-ester enolate, a potential synthetic equivalent to the γ-anion synthon for stereospecific α-amino acid synthesis.

Bibliographic Details
Main Authors: Baldwin, J, North, M, Flinn, A, Moloney, M
Format: Journal article
Language:English
Published: 1988