A phase II clinical trial of 6-mercaptopurine (6MP) and methotrexate in patients with BRCA defective tumours: a study protocol

<p><strong>Background</strong> BRCA1 and BRCA2 genes are critical in homologous recombination DNA repair and have been implicated in familial breast and ovarian cancer tumorigenesis. Tumour cells with these mutations demonstrate increased sensitivity to cisplatin and poly (ADP-ribo...

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Détails bibliographiques
Auteurs principaux: Nicum, S, Roberts, C, Boyle, L, Kopijasz, S, Gourley, C, Hall, M, Montes, A, Poole, C, Collins, L, Schuh, A, Dutton, S
Format: Journal article
Langue:English
Publié: BioMed Central 2014