Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 i...

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Main Authors: Randall, J, Winkler, T, Kutalik, Z, Berndt, S, Jackson, A, Monda, K, Kilpeläinen, T, Esko, T, Mägi, R, Li, S, Workalemahu, T, Feitosa, M, Croteau-Chonka, D, Day, F, Fall, T, Ferreira, T, Gustafsson, S, Locke, A, Mathieson, I, Scherag, A, Vedantam, S, Wood, A, Liang, L, Steinthorsdottir, V, Thorleifsson, G, Dermitzakis, E, Dimas, A, Karpe, F, Min, J, Nicholson, G, Clegg, D, Person, T, Krohn, J, Bauer, S, Buechler, C, Eisinger, K, Bonnefond, A, Froguel, P, Hottenga, J, Prokopenko, I, Waite, L, Harris, T, Smith, A, Shuldiner, A, McArdle, W, Caulfield, M, Munroe, P, Grönberg, H, Chen, Y, Li, G, Beckmann, J, Johnson, T, Thorsteinsdottir, U, Teder-Laving, M, Khaw, K, Wareham, N, Zhao, J, Amin, N, Oostra, B, Kraja, A, Province, M, Cupples, L, Heard-Costa, N, Kaprio, J, Ripatti, S, Surakka, I, Collins, F, Saramies, J, Tuomilehto, J, Jula, A, Salomaa, V, Erdmann, J, Hengstenberg, C, Loley, C, Schunkert, H, Lamina, C, Wichmann, H, Albrecht, E, Gieger, C, Hicks, A, Johansson, A, Pramstaller, P, Kathiresan, S, Speliotes, E, Penninx, B, Hartikainen, A, Jarvelin, MR, Gyllensten, U, Boomsma, D, Campbell, H, Wilson, J, Chanock, S, Farrall, M, Goel, A, Medina-Gomez, C, Rivadeneira, F, Estrada, K, Uitterlinden, A, Hofman, A, Zillikens, M, Den Heijer, M, Kiemeney, L, Maschio, A, Hall, P, Tyrer, J, Teumer, A, Völzke, H, Kovacs, P, Tönjes, A, Mangino, M, Spector, T, Hayward, C, Rudan, I, Hall, A, Samani, N, Attwood, A, Sambrook, J, Hung, J, Palmer, L, Lokki, M, Sinisalo, J, Boucher, G, Huikuri, H, Lorentzon, M, Ohlsson, C, Eklund, N, Eriksson, J, Barlassina, C, Rivolta, C, Nolte, I, Snieder, H, Van Der Klauw, MM, Van Vliet-Ostaptchouk, J, Gejman, P, Shi, J, Jacobs, K, Wang, Z, Bakker, S, Mateo Leach, I, Navis, G, Van Der Harst, P, Martin, N, Medland, SE, Montgomery, G, Yang, J, Chasman, D, Ridker, P, Rose, L, Lehtimäki, T, Raitakari, O, Absher, D, Iribarren, C, Basart, H, Hovingh, K, Hyppönen, E, Power, C, Anderson, D, Beilby, J, Hui, J, Jolley, J, Sager, H, Bornstein, SR, Schwarz, P, Kristiansson, K, Perola, M, Lindström, J, Swift, A, Uusitupa, M, Atalay, M, Lakka, T, Rauramaa, R, Bolton, J, Fowkes, G, Fraser, R, Price, J, Fischer, K, Krjutå Kov, K, Metspalu, A, Mihailov, E, Langenberg, C, Luan, J, Ong, K, Chines, P, Keinanen-Kiukaanniemi, S, Saaristo, T, Edkins, S, Franks, P, Hallmans, G, Shungin, D, Morris, A, Palmer, C, Erbel, R, Moebus, S, Nöthen, M, Pechlivanis, S, Hveem, K, Narisu, N, Hamsten, A, Humphries, SE, Strawbridge, R, Tremoli, E, Grallert, H, Thorand, B, Illig, T, Koenig, W, Müller-Nurasyid, M, Peters, A, Boehm, B, Kleber, M, März, W, Winkelmann, B, Kuusisto, J, Laakso, M, Arveiler, D, Cesana, G, Kuulasmaa, K, Virtamo, J, Yarnell, J, Kuh, D, Wong, A, Lind, L, De Faire, U, Gigante, B, Magnusson, P, Pedersen, N, Dedoussis, G, Dimitriou, M, Kolovou, G, Kanoni, S, Stirrups, K, Bonnycastle, L, Njølstad, I, Wilsgaard, T, Ganna, A, Rehnberg, E, Hingorani, A, Kivimaki, M, Kumari, M, Assimes, T, Barroso, I, Boehnke, M, Borecki, I, Deloukas, P, Fox, C, Frayling, T, Groop, L, Haritunians, T, Hunter, D, Ingelsson, E, Kaplan, R, Mohlke, K, O'Connell, JR, Schlessinger, D, Strachan, D, Stefansson, K, Van Duijn, C, Abecasis, G, McCarthy, M, Hirschhorn, J, Qi, L, Loos, R, Lindgren, C, North, K, Heid, I
Format: Journal article
Language:English
Published: Public Library of Science 2013