Conformational changes in the epidermal growth factor receptor: role of the transmembrane domain investigated by Coarse-Grained metadynamics free energy calculations
The epidermal growth factor receptor (EGFR) is a dimeric membrane protein which regulates key aspects of cellular function. Activation of the EGFR is linked to changes in the conformation of the transmembrane (TM) domain, brought about by changes in interactions of the TM helices of the membrane lip...
| Main Authors: | , , |
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| Format: | Journal article |
| Published: |
American Chemical Society
2016
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