'Chemical co-substrate rescue' of phytanoyl-CoA 2-hydroxylase mutants causing Refsum's Disease
The in vitro catalytic activity of two clinically observed mutants of phytanoyl-CoA 2-hydroxylase, an iron(II)/2-oxoglutarate-dependent oxygenase causing Refsum's Disease, was partially rescued by the use of alternatives to the natural cosubstrate, 2-oxoglutarate; this is the first demonstratio...
Full beskrivning
Bibliografiska uppgifter
| Huvudupphovsmän: |
Mukherji, M,
Kershaw, N,
MacKinnon, C,
Clifton, I,
Wierzbicki, A,
Schofield, C,
Lloyd, MD |
|---|
| Materialtyp: | Journal article
|
|---|
| Språk: | English |
|---|
| Publicerad: |
2001
|
|---|