The therapeutic potential of O6-alkylguanine DNA alkyltransferase inhibitors.
Resistance to O(6-)alkylating agents can be overcome by depletion of the DNA repair protein, O(6)-alkylguanine DNA alkyltransferase. Inhibitors of this protein act as pseudosubstrates and, so far, O(6)-benzylguanine and lomeguatrib have been tested in clinical trials. Inherently non-toxic, optimum d...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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