cGMP-inhibited phosphodiesterase of cAMP (PDE3) and protein kinase a (PKA) play an important role in eliciting the positive chronotropic effect of Nitric Oxide (NO) donors
Background: NO donors exert a positive chronotropic effect by stimulating the pacemaker current If in sino-atrial node cells via a mechanism requiring guanylyl cyclase (GC) and cGMP, and involving mobilization of sarcoplasmic (SR) Ca2+. Cyclic GMP can directly stimulate If but it is ∼10-fold less po...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2000
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