The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility
The serine and threonine kinase MST1 is the mammalian homolog of Hippo. MST1 is a critical mediator of the migration, adhesion, and survival of T cells; however, these functions of MST1 are independent of signaling by its typical effectors, the kinase LATS and the transcriptional coactivator YAP. Th...
| Հիմնական հեղինակներ: | , , , , , , , , , , , , , , , , |
|---|---|
| Ձևաչափ: | Journal article |
| Հրապարակվել է: |
American Association for the Advancement of Science
2015
|