Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load

Objectives: Although CD8+ T cells play a critical role in the control of HIV-1 infection, their antiviral efficacy can be limited by antigenic variation and immune exhaustion. The latter phenomenon is characterized by the upregulation of multiple inhibitory receptors, such as programmed death-1 (PD-...

תיאור מלא

מידע ביבליוגרפי
Main Authors: Kløverpris, H, McGregor, R, McLaren, J, Ladell, K, Stryhn, A, Koofhethile, C, Brener, J, Chen, F, Riddell, L, Graziano, L, Klenerman, P, Leslie, A, Buus, S, Price, D, Goulder, P
פורמט: Journal article
שפה:English
יצא לאור: Lippincott Williams and Wilkins 2014