Somatic mutations of GNA11 and GNAQ in CTNNB1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause

Somatic mutations of GNA11 and GNAQ in CTNNB1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause

Most aldosterone-producing adenomas (APAs) have gain-of-function somatic mutations of ion channels or transporters. However, their frequency in aldosterone-producing cell clusters of normal adrenal gland suggests a requirement for codriver mutations in APAs. Here we identified gain-of-function mutat...

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Bibliographic Details
Main Authors: Zhou, J, Azizan, EAB, Cabrera, CP, Fernandes-Rosa, FL, Boulkroun, S, Argentesi, G, Cottrell, E, Amar, L, Wu, X, O'Tool, S, Goodchild, E, Marker, A, Senanayake, R, Garg, S, Åkerstrom, T, Backman, S, Jordan, S, Polubothu, S, Berney, DM, Gluck, A, Lines, KE, Thakker, RV, Tuthill, A, Joyce, C, Kaski, JP, Karet Frankl, FE, Metherell, LA, Teo, AED, Gurnell, M, Parvanta, L, Drake, WM, Wozniak, E, Klinzing, D, Kuan, JL, Tiang, Z, Gomez Sanchez, CE, Hellman, P, Foo, RSY, Mein, CA, Kinsler, VA, Björklund, P, Storr, HL, Zennaro, M-C, Brown, MJ
Format: Journal article
Language:English
Published: Springer Nature 2021

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