Not all Wnt activation is equal: ligand-dependent versus ligand-independent wnt activation in colorectal cancer
Wnt signaling is ubiquitously activated in colorectal tumors and driver mutations are identified in genes such as APC, CTNNB1, RNF43 and R-spondin (RSPO2/3). Adenomatous polyposis coli (APC) and CTNNB1 mutations lead to downstream constitutive activation (ligand-independent), while RNF43 and RSPO mu...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
MDPI
2020
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