Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages' transition into a pro-inflammatory state

Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages' transition into a pro-inflammatory state

<p><strong>Aims:&nbsp;</strong>CD40 and its ligand, CD40L, play a critical role in driving atherosclerotic plaque development. Disrupted CD40-signalling reduces experimental atherosclerosis and induces a favourable stable plaque phenotype. We recently showed that small molecule...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Bosmans, LA, van Tiel, CM, Aarts, SABM, Willemsen, L, Baardman, J, van Os, BW, den Toom, M, Beckers, L, Ahern, DJ, Levels, JHM, Jongejan, A, Moerland, PD, Verberk, SGS, van den Bossche, J, de Winther, MMPJ, Weber, C, Atzler, D, Monaco, C, Gerdes, N, Shami, A, Lutgens, E
Format: Journal article
Sprache:English
Veröffentlicht: Oxford University Press 2022

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