Endoplasmic reticulum aminopeptidase 1 (ERAP1) plays a critical role in determining the length and sequence of peptides bound and presented by HLA-B27

Endoplasmic reticulum aminopeptidase 1 (ERAP1) plays a critical role in determining the length and sequence of peptides bound and presented by HLA-B27

<p><strong>Objective.</strong> HLA-B27 and ERAP1 are the two strongest predisposing genetic factors to Ankylosing Spondylitis (AS). A key aminopeptidase in MHC class I presentation, ERAP1 potentially contributes to AS pathogenesis through altering HLA-B27 peptide presentation. We s...

Full description

Bibliographic Details
Main Authors: Chen, L, Fischer, R, Peng, Y, Reeves, E, McHugh, K, Ternette, N, Hanke, T, Dong, T, Elliott, T, Shastri, N, Kollnberger, S, James, E, Bowness, P
Other Authors: American College of Rheumatology
Format: Journal article
Language:English
Published: Wiley-Blackwell 2013
Subjects:
Medical sciences
Immunology
Rheumotology

Similar Items