Small-molecule inhibition of BRDT for male contraception.

A pharmacologic approach to male contraception remains a longstanding challenge in medicine. Toward this objective, we explored the spermatogenic effects of a selective small-molecule inhibitor (JQ1) of the bromodomain and extraterminal (BET) subfamily of epigenetic reader proteins. Here, we report...

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Bibliographic Details
Main Authors: Matzuk, M, McKeown, MR, Filippakopoulos, P, Li, Q, Ma, L, Agno, J, Lemieux, M, Picaud, S, Yu, R, Qi, J, Knapp, S, Bradner, J
Format: Journal article
Language:English
Published: 2012