Efficiency of Xist-mediated silencing on autosomes is linked to chromosomal domain organisation.
BACKGROUND: X chromosome inactivation, the mechanism used by mammals to equalise dosage of X-linked genes in XX females relative to XY males, is triggered by chromosome-wide localisation of a cis-acting non-coding RNA, Xist. The mechanism of Xist RNA spreading and Xist-dependent silencing is poorly...
मुख्य लेखकों: | Tang, Y, Huntley, D, Montana, G, Cerase, A, Nesterova, T, Brockdorff, N |
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स्वरूप: | Journal article |
भाषा: | English |
प्रकाशित: |
2010
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समान संसाधन
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Efficiency of Xist-mediated silencing on autosomes is linked to chromosomal domain organisation
द्वारा: Tang Y Amy, और अन्य
प्रकाशित: (2010-05-01) -
Linking Chromosomal Silencing With Xist Expression From Autosomal Integrated Transgenes
द्वारा: Ikrame Naciri, और अन्य
प्रकाशित: (2021-06-01) -
hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to establish polycomb-mediated chromosomal silencing
द्वारा: Pintacuda, G, और अन्य
प्रकाशित: (2017) -
Disruption of a conserved region of Xist exon 1 impairs Xist RNA localisation and X-linked gene silencing during random and imprinted X chromosome inactivation.
द्वारा: Senner, C, और अन्य
प्रकाशित: (2011) -
Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations
द्वारा: Agnese Loda, और अन्य
प्रकाशित: (2017-09-01)