FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity.

Naturally occurring variation in gene copy number is increasingly recognized as a heritable source of susceptibility to genetically complex diseases. Here we report strong association between FCGR3B copy number and risk of systemic lupus erythematosus (P = 2.7 x 10(-8)), microscopic polyangiitis (P...

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Bibliographic Details
Main Authors: Fanciulli, M, Norsworthy, P, Petretto, E, Dong, R, Harper, L, Kamesh, L, Heward, J, Gough, S, de Smith, A, Blakemore, A, Froguel, P, Owen, C, Pearce, S, Teixeira, L, Guillevin, L, Graham, D, Pusey, C, Cook, H, Vyse, T, Aitman, T
Format: Journal article
Language:English
Published: 2007