Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex

The aryl hydrocarbon receptor (AHR) possesses an extraordinary capacity to sense and respond to a wide range of small-molecule ligands, ranging from polycyclic aromatic hydrocarbons to endogenous compounds. Upon ligand binding, AHR translocates from the cytoplasm to nucleus, forming a transcriptiona...

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Bibliographic Details
Main Authors: Diao, X, Shang, Q, Guo, M, Huang, Y, Zhang, M, Chen, X, Liang, Y, Sun, X, Zhou, F, Zhuang, J, Liu, S, Vogel, CFA, Rastinejad, F, Wu, D
Format: Journal article
Language:English
Published: Nature Research 2025