Quantitative contribution of CD4 and CD8 to T cell antigen receptor serial triggering.

CD4 and CD8 are thought to function as coreceptors by binding to the cognate major histocompatibility complex (MHC) molecules recognized by the T cell antigen receptor (TCR) and initiating the signal transduction cascade. We report that during T cell-antigen-presenting cell interaction, triggered TC...

Full description

Bibliographic Details
Main Authors: Viola, A, Salio, M, Tuosto, L, Linkert, S, Acuto, O, Lanzavecchia, A
Format: Journal article
Language:English
Published: 1997