18F-trifluoromethylation of unmodified peptides with 5-18F-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate
The 18F-labeling of 5-(trifluoromethyl)-dibenzothiophenium trifluoromethanesulfonate, commonly referred to as the Umemoto reagent, has been accomplished applying a halogen exchange 18F-fluorination with 18F-fluoride, followed by oxidative cyclization with Oxone and trifluoromethanesulfonic anhydride...
| Κύριοι συγγραφείς: | , , , , , , , , , |
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| Μορφή: | Journal article |
| Γλώσσα: | English |
| Έκδοση: |
American Chemical Society
2018
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| _version_ | 1826297117233119232 |
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| author | Verhoog, S Kee, C Wang, Y Khotavivattana, T Wilson, T Kersemans, V Smart, S Tredwell, M Davis, B Gouverneur, V |
| author_facet | Verhoog, S Kee, C Wang, Y Khotavivattana, T Wilson, T Kersemans, V Smart, S Tredwell, M Davis, B Gouverneur, V |
| author_sort | Verhoog, S |
| collection | OXFORD |
| description | The 18F-labeling of 5-(trifluoromethyl)-dibenzothiophenium trifluoromethanesulfonate, commonly referred to as the Umemoto reagent, has been accomplished applying a halogen exchange 18F-fluorination with 18F-fluoride, followed by oxidative cyclization with Oxone and trifluoromethanesulfonic anhydride. This new 18F-reagent allows for the direct chemoselective 18F-labeling of unmodified peptides at the thiol cysteine residue. |
| first_indexed | 2024-03-07T04:26:41Z |
| format | Journal article |
| id | oxford-uuid:cce0b7b2-555b-4638-9ab8-35d91d03104d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:26:41Z |
| publishDate | 2018 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | oxford-uuid:cce0b7b2-555b-4638-9ab8-35d91d03104d2022-03-27T07:24:56Z18F-trifluoromethylation of unmodified peptides with 5-18F-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonateJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cce0b7b2-555b-4638-9ab8-35d91d03104dEnglishSymplectic Elements at OxfordAmerican Chemical Society2018Verhoog, SKee, CWang, YKhotavivattana, TWilson, TKersemans, VSmart, STredwell, MDavis, BGouverneur, VThe 18F-labeling of 5-(trifluoromethyl)-dibenzothiophenium trifluoromethanesulfonate, commonly referred to as the Umemoto reagent, has been accomplished applying a halogen exchange 18F-fluorination with 18F-fluoride, followed by oxidative cyclization with Oxone and trifluoromethanesulfonic anhydride. This new 18F-reagent allows for the direct chemoselective 18F-labeling of unmodified peptides at the thiol cysteine residue. |
| spellingShingle | Verhoog, S Kee, C Wang, Y Khotavivattana, T Wilson, T Kersemans, V Smart, S Tredwell, M Davis, B Gouverneur, V 18F-trifluoromethylation of unmodified peptides with 5-18F-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate |
| title | 18F-trifluoromethylation of unmodified peptides with 5-18F-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate |
| title_full | 18F-trifluoromethylation of unmodified peptides with 5-18F-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate |
| title_fullStr | 18F-trifluoromethylation of unmodified peptides with 5-18F-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate |
| title_full_unstemmed | 18F-trifluoromethylation of unmodified peptides with 5-18F-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate |
| title_short | 18F-trifluoromethylation of unmodified peptides with 5-18F-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate |
| title_sort | 18f trifluoromethylation of unmodified peptides with 5 18f trifluoromethyl dibenzothiophenium trifluoromethanesulfonate |
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