Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development

B lymphocyte development and selection are central to adaptive immunity and self-tolerance. These processes require B cell receptor (BCR) signaling and occur in bone marrow, an environment with variable hypoxia, but whether hypoxia-inducible factor (HIF) is involved is unknown. We show that HIF acti...

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Detaylı Bibliyografya
Asıl Yazarlar:	Burrows, N, Bashford-Rogers, RJM, Bhute, VJ, Peñalver, A, Ferdinand, JR, Stewart, BJ, Smith, JEG, Deobagkar-Lele, M, Giudice, G, Connor, TM, Inaba, A, Bergamaschi, L, Smith, S, Tran, MGB, Petsalaki, E, Lyons, PA, Espeli, M, Huntly, BJP, Smith, KGC, Cornall, RJ, Clatworthy, MR, Maxwell, PH
Materyal Türü:	Journal article
Dil:	English
Baskı/Yayın Bilgisi:	Springer Nature 2020

Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development

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