Mechanistic and inhibition studies on isocitrate dehydrogenase 1

<p>Genes encoding for IDH1 and IDH2 are frequently mutated in multiple cancer types including gliomas and AML. IDH variants, notably R132H IDH1, result in a gain-offunction leading to substantially enhanced production of the ‘oncometabolite’, 2- hydroxyglutarate. Drug development by pharmaceut...

תיאור מלא

מידע ביבליוגרפי
מחבר ראשי: Liu, S
מחברים אחרים: Schofield, C
פורמט: Thesis
שפה:English
יצא לאור: 2019