Mechanistic and inhibition studies on isocitrate dehydrogenase 1

Mechanistic and inhibition studies on isocitrate dehydrogenase 1

<p>Genes encoding for IDH1 and IDH2 are frequently mutated in multiple cancer types including gliomas and AML. IDH variants, notably R132H IDH1, result in a gain-offunction leading to substantially enhanced production of the ‘oncometabolite’, 2- hydroxyglutarate. Drug development by pharmaceut...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoir:	Liu, S
Rannpháirtithe:	Schofield, C
Formáid:	Tráchtas
Teanga:	English
Foilsithe / Cruthaithe:	2019

Míreanna comhchosúla

The studies on the mechanism and inhibition of Isocitrate Dehydrogenases
de réir: Liu, X
Foilsithe / Cruthaithe: (2022)

Mutation of Isocitrate Dehydrogenase 1 in Cholangiocarcinoma Impairs Tumor Progression by Inhibiting Isocitrate Metabolism
de réir: Li Su, et al.
Foilsithe / Cruthaithe: (2020-04-01)

How robust are the data in vorasidenib for isocitrate dehydrogenase-1 or isocitrate dehydrogenase-2 mutant low-grade glioma?
de réir: Eric T Wong
Foilsithe / Cruthaithe: (2023-01-01)

Highlighting the mechanistic role of Olutasidenib (FT-2102) in the selective inhibition of mutated isocitrate dehydrogenase 1 (mIDH1) in cancer therapy
de réir: Elliasu Y. Salifu, et al.
Foilsithe / Cruthaithe: (2022-01-01)

Differentiating inhibition selectivity and binding affinity of isocitrate dehydrogenase 1 variant inhibitors
de réir: Liu, S, et al.
Foilsithe / Cruthaithe: (2023)

Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1
de réir: Liu, S, et al.
Foilsithe / Cruthaithe: (2021)

Inhibitors of mutant isocitrate dehydrogenase for isocitrate dehydrogenase-mutant gliomas: A new standard of care?
de réir: Emilie Le Rhun, et al.
Foilsithe / Cruthaithe: (2024-01-01)

Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1
de réir: Shuang Liu, et al.
Foilsithe / Cruthaithe: (2021-11-01)

The regulatory mechanisms and inhibitors of isocitrate dehydrogenase 1 in cancer
de réir: Yang Liu, et al.
Foilsithe / Cruthaithe: (2023-04-01)

Isocitrate dehydrogenase inhibitors in acute myeloid leukemia
de réir: Xiaoyan Liu, et al.
Foilsithe / Cruthaithe: (2019-10-01)

Studies on human cancer variant and mycobacterial isocitrate dehydrogenases
de réir: Reinbold, R
Foilsithe / Cruthaithe: (2021)

The Role of Isocitrate Dehydrogenases in Direct Reprogramming to Cardiomyocytes
de réir: Tomoaki Ishida, et al.
Foilsithe / Cruthaithe: (2021-12-01)

Isocitrate Dehydrogenase 1 and 2 Mutations in Pediatric Neuroblastoma Patients
de réir: Emre LEVENTOGLU, et al.
Foilsithe / Cruthaithe: (2023-06-01)

Mutasi Isocitrate Dehydrogenase 1 dan 2 pada Glioma
de réir: Ni Putu Sriwidyani
Foilsithe / Cruthaithe: (2020-12-01)

Functional analysis of mutations in isocitrate dehydrogenase involved in gliomagenesis
de réir: Krell, D
Foilsithe / Cruthaithe: (2014)

Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations
de réir: Hvinden, IC, et al.
Foilsithe / Cruthaithe: (2021)

Isocitrate dehydrogenase gene variants in cancer and their clinical significance
de réir: Cadoux-Hudson, T, et al.
Foilsithe / Cruthaithe: (2021)

Cytosolic NADP-isocitrate dehydrogenase in Arabidopsis leaves and roots
de réir: M. Leterrier, et al.
Foilsithe / Cruthaithe: (2012-12-01)

Isocitrate Dehydrogenase Inhibitors in Glioma: From Bench to Bedside
de réir: Merve Hazal Ser, et al.
Foilsithe / Cruthaithe: (2024-05-01)

Mutant Isocitrate Dehydrogenase Inhibitors as Targeted Cancer Therapeutics
de réir: Danielle Golub, et al.
Foilsithe / Cruthaithe: (2019-05-01)

Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight
de réir: Hamoud Al-Khallaf
Foilsithe / Cruthaithe: (2017-08-01)

Research Progress of Isocitrate Dehydrogenase Gene Mutation Therapy
de réir: LIN Meijia, et al.
Foilsithe / Cruthaithe: (2023-03-01)

Isocitrate dehydrogenase 1 and 2 genes mutations and MGMT methylation in gliomas
de réir: D. V. Tabakov, et al.
Foilsithe / Cruthaithe: (2017-04-01)

Advances in Immune Microenvironment and Immunotherapy of Isocitrate Dehydrogenase Mutated Glioma
de réir: Dongming Yan, et al.
Foilsithe / Cruthaithe: (2022-06-01)

Isocitrate dehydrogenase variants in cancer — Cellular consequences and therapeutic opportunities
de réir: Liu, S, et al.
Foilsithe / Cruthaithe: (2020)

Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase
de réir: Pengkai Sun, et al.
Foilsithe / Cruthaithe: (2020-12-01)

Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH).
de réir: Jinsung Yang, et al.
Foilsithe / Cruthaithe: (2017-08-01)

Isocitrate Dehydrogenase Mutations in Glioma: Genetics, Biochemistry, and Clinical Indications
de réir: Yang Liu, et al.
Foilsithe / Cruthaithe: (2020-08-01)

Discovery of novel enasidenib analogues targeting inhibition of mutant isocitrate dehydrogenase 2 as antileukaemic agents
de réir: Ahmed F. Khalil, et al.
Foilsithe / Cruthaithe: (2023-12-01)

Isocitrate dehydrogenase 1 mutation subtypes at site 132 and their translational potential in glioma
de réir: Victor M Lu, et al.
Foilsithe / Cruthaithe: (2018-01-01)

Isocitrate dehydrogenase 1 mutation is associated with reduced levels of inflammation in glioma patients
de réir: Auezova R, et al.
Foilsithe / Cruthaithe: (2019-04-01)

A novel isocitrate dehydrogenase 1 G131D mutation in glioblastoma
de réir: Lei-Ming Wang, et al.
Foilsithe / Cruthaithe: (2021-02-01)

The Role of Mitochondrial NADPH-Dependent Isocitrate Dehydrogenase in Cancer Cells
de réir: Katarína Smolková, et al.
Foilsithe / Cruthaithe: (2012-01-01)

Cytosolic Isocitrate Dehydrogenase from Arabidopsis thaliana Is Regulated by Glutathionylation
de réir: Adnan Khan Niazi, et al.
Foilsithe / Cruthaithe: (2019-01-01)

Research Progress and Prospects of Isocitrate Dehydrogenase Gene Mutation in Chondrosarcoma
de réir: ZHAO Jingjing, ZHANG Zhihong, ZHEN Junping
Foilsithe / Cruthaithe: (2024-04-01)

Identification of potential target genes for isocitrate dehydrogenase mutations in cholangiocarcinoma
de réir: WANG Di, LI Qing, TONG Wei-min, NIU Ya-mei
Foilsithe / Cruthaithe: (2020-04-01)

Isocitrate dehydrogenase 1 Gene Mutation Is Associated with Prognosis in Clinical Low-Grade Gliomas.
de réir: Ming-Yang Li, et al.
Foilsithe / Cruthaithe: (2015-01-01)

Stochastic Microsensors Based on Carbon Nanotubes for Molecular Recognition of the Isocitrate Dehydrogenases 1 and 2
de réir: Raluca-Ioana Stefan-van Staden, et al.
Foilsithe / Cruthaithe: (2022-01-01)

Isocitrate dehydrogenase 1 mutation in cholangiocarcinoma impairs tumor progression by sensitizing cells to ferroptosis
de réir: Su Li, et al.
Foilsithe / Cruthaithe: (2022-05-01)

Investigating isocitrate dehydrogenase mutations in cancer using new metabolomics methods
de réir: Walsby-Tickle, J
Foilsithe / Cruthaithe: (2020)