Mechanistic and inhibition studies on isocitrate dehydrogenase 1

<p>Genes encoding for IDH1 and IDH2 are frequently mutated in multiple cancer types including gliomas and AML. IDH variants, notably R132H IDH1, result in a gain-offunction leading to substantially enhanced production of the ‘oncometabolite’, 2- hydroxyglutarate. Drug development by pharmaceut...

Descrición completa

Detalles Bibliográficos
Autor Principal: Liu, S
Outros autores: Schofield, C
Formato: Thesis
Idioma:English
Publicado: 2019

Títulos similares