Mechanistic and inhibition studies on isocitrate dehydrogenase 1

Mechanistic and inhibition studies on isocitrate dehydrogenase 1

<p>Genes encoding for IDH1 and IDH2 are frequently mutated in multiple cancer types including gliomas and AML. IDH variants, notably R132H IDH1, result in a gain-offunction leading to substantially enhanced production of the ‘oncometabolite’, 2- hydroxyglutarate. Drug development by pharmaceut...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखक:	Liu, S
अन्य लेखक:	Schofield, C
स्वरूप:	थीसिस
भाषा:	English
प्रकाशित:	2019

समान संसाधन

The studies on the mechanism and inhibition of Isocitrate Dehydrogenases
द्वारा: Liu, X
प्रकाशित: (2022)

Mutation of Isocitrate Dehydrogenase 1 in Cholangiocarcinoma Impairs Tumor Progression by Inhibiting Isocitrate Metabolism
द्वारा: Li Su, और अन्य
प्रकाशित: (2020-04-01)

How robust are the data in vorasidenib for isocitrate dehydrogenase-1 or isocitrate dehydrogenase-2 mutant low-grade glioma?
द्वारा: Eric T Wong
प्रकाशित: (2023-01-01)

Highlighting the mechanistic role of Olutasidenib (FT-2102) in the selective inhibition of mutated isocitrate dehydrogenase 1 (mIDH1) in cancer therapy
द्वारा: Elliasu Y. Salifu, और अन्य
प्रकाशित: (2022-01-01)

Differentiating inhibition selectivity and binding affinity of isocitrate dehydrogenase 1 variant inhibitors
द्वारा: Liu, S, और अन्य
प्रकाशित: (2023)

Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1
द्वारा: Liu, S, और अन्य
प्रकाशित: (2021)

Inhibitors of mutant isocitrate dehydrogenase for isocitrate dehydrogenase-mutant gliomas: A new standard of care?
द्वारा: Emilie Le Rhun, और अन्य
प्रकाशित: (2024-01-01)

Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1
द्वारा: Shuang Liu, और अन्य
प्रकाशित: (2021-11-01)

The regulatory mechanisms and inhibitors of isocitrate dehydrogenase 1 in cancer
द्वारा: Yang Liu, और अन्य
प्रकाशित: (2023-04-01)

Isocitrate dehydrogenase inhibitors in acute myeloid leukemia
द्वारा: Xiaoyan Liu, और अन्य
प्रकाशित: (2019-10-01)

Studies on human cancer variant and mycobacterial isocitrate dehydrogenases
द्वारा: Reinbold, R
प्रकाशित: (2021)

The Role of Isocitrate Dehydrogenases in Direct Reprogramming to Cardiomyocytes
द्वारा: Tomoaki Ishida, और अन्य
प्रकाशित: (2021-12-01)

Isocitrate Dehydrogenase 1 and 2 Mutations in Pediatric Neuroblastoma Patients
द्वारा: Emre LEVENTOGLU, और अन्य
प्रकाशित: (2023-06-01)

Mutasi Isocitrate Dehydrogenase 1 dan 2 pada Glioma
द्वारा: Ni Putu Sriwidyani
प्रकाशित: (2020-12-01)

Functional analysis of mutations in isocitrate dehydrogenase involved in gliomagenesis
द्वारा: Krell, D
प्रकाशित: (2014)

Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations
द्वारा: Hvinden, IC, और अन्य
प्रकाशित: (2021)

Isocitrate dehydrogenase gene variants in cancer and their clinical significance
द्वारा: Cadoux-Hudson, T, और अन्य
प्रकाशित: (2021)

Cytosolic NADP-isocitrate dehydrogenase in Arabidopsis leaves and roots
द्वारा: M. Leterrier, और अन्य
प्रकाशित: (2012-12-01)

Isocitrate Dehydrogenase Inhibitors in Glioma: From Bench to Bedside
द्वारा: Merve Hazal Ser, और अन्य
प्रकाशित: (2024-05-01)

Mutant Isocitrate Dehydrogenase Inhibitors as Targeted Cancer Therapeutics
द्वारा: Danielle Golub, और अन्य
प्रकाशित: (2019-05-01)

Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight
द्वारा: Hamoud Al-Khallaf
प्रकाशित: (2017-08-01)

Research Progress of Isocitrate Dehydrogenase Gene Mutation Therapy
द्वारा: LIN Meijia, और अन्य
प्रकाशित: (2023-03-01)

Isocitrate dehydrogenase 1 and 2 genes mutations and MGMT methylation in gliomas
द्वारा: D. V. Tabakov, और अन्य
प्रकाशित: (2017-04-01)

Advances in Immune Microenvironment and Immunotherapy of Isocitrate Dehydrogenase Mutated Glioma
द्वारा: Dongming Yan, और अन्य
प्रकाशित: (2022-06-01)

Isocitrate dehydrogenase variants in cancer — Cellular consequences and therapeutic opportunities
द्वारा: Liu, S, और अन्य
प्रकाशित: (2020)

Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase
द्वारा: Pengkai Sun, और अन्य
प्रकाशित: (2020-12-01)

Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH).
द्वारा: Jinsung Yang, और अन्य
प्रकाशित: (2017-08-01)

Isocitrate Dehydrogenase Mutations in Glioma: Genetics, Biochemistry, and Clinical Indications
द्वारा: Yang Liu, और अन्य
प्रकाशित: (2020-08-01)

Discovery of novel enasidenib analogues targeting inhibition of mutant isocitrate dehydrogenase 2 as antileukaemic agents
द्वारा: Ahmed F. Khalil, और अन्य
प्रकाशित: (2023-12-01)

Isocitrate dehydrogenase 1 mutation subtypes at site 132 and their translational potential in glioma
द्वारा: Victor M Lu, और अन्य
प्रकाशित: (2018-01-01)

Isocitrate dehydrogenase 1 mutation is associated with reduced levels of inflammation in glioma patients
द्वारा: Auezova R, और अन्य
प्रकाशित: (2019-04-01)

A novel isocitrate dehydrogenase 1 G131D mutation in glioblastoma
द्वारा: Lei-Ming Wang, और अन्य
प्रकाशित: (2021-02-01)

The Role of Mitochondrial NADPH-Dependent Isocitrate Dehydrogenase in Cancer Cells
द्वारा: Katarína Smolková, और अन्य
प्रकाशित: (2012-01-01)

Cytosolic Isocitrate Dehydrogenase from Arabidopsis thaliana Is Regulated by Glutathionylation
द्वारा: Adnan Khan Niazi, और अन्य
प्रकाशित: (2019-01-01)

Research Progress and Prospects of Isocitrate Dehydrogenase Gene Mutation in Chondrosarcoma
द्वारा: ZHAO Jingjing, ZHANG Zhihong, ZHEN Junping
प्रकाशित: (2024-04-01)

Identification of potential target genes for isocitrate dehydrogenase mutations in cholangiocarcinoma
द्वारा: WANG Di, LI Qing, TONG Wei-min, NIU Ya-mei
प्रकाशित: (2020-04-01)

Isocitrate dehydrogenase 1 Gene Mutation Is Associated with Prognosis in Clinical Low-Grade Gliomas.
द्वारा: Ming-Yang Li, और अन्य
प्रकाशित: (2015-01-01)

Stochastic Microsensors Based on Carbon Nanotubes for Molecular Recognition of the Isocitrate Dehydrogenases 1 and 2
द्वारा: Raluca-Ioana Stefan-van Staden, और अन्य
प्रकाशित: (2022-01-01)

Isocitrate dehydrogenase 1 mutation in cholangiocarcinoma impairs tumor progression by sensitizing cells to ferroptosis
द्वारा: Su Li, और अन्य
प्रकाशित: (2022-05-01)

Investigating isocitrate dehydrogenase mutations in cancer using new metabolomics methods
द्वारा: Walsby-Tickle, J
प्रकाशित: (2020)