Folate-sensitive fragile site FRA10A is due to an expansion of a CGG repeat in a novel gene, FRA10AC1, encoding a nuclear protein.

Fragile sites appear visually as nonstaining gaps on chromosomes that are inducible by specific cell culture conditions. Expansion of CGG/CCG repeats has been shown to be the molecular basis of all five folate-sensitive fragile sites characterized molecularly so far, i.e., FRAXA, FRAXE, FRAXF, FRA11...

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Hlavní autoři:	Sarafidou, T, Kahl, C, Martinez-Garay, I, Mangelsdorf, M, Gesk, S, Baker, E, Kokkinaki, M, Talley, P, Maltby, E, French, L, Harder, L, Hinzmann, B, Nobile, C, Richkind, K, Finnis, M, Deloukas, P, Sutherland, G, Kutsche, K, Moschonas, N, Siebert, R, Gécz, J
Médium:	Journal article
Jazyk:	English
Vydáno:	2004

Folate-sensitive fragile site FRA10A is due to an expansion of a CGG repeat in a novel gene, FRA10AC1, encoding a nuclear protein.

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