Identification of plasma proteomic markers underlying polygenic risk of type 2 diabetes and related comorbidities

Genomics can provide insight into the etiology of type 2 diabetes and its comorbidities, but assigning functionality to non-coding variants remains challenging. Polygenic scores, which aggregate variant effects, can uncover mechanisms when paired with molecular data. Here, we test polygenic scores f...

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Bibliographic Details
Main Authors: Loesch, DP, Garg, M, Matelska, D, Vitsios, D, Jiang, X, Ritchie, SC, Sun, BB, Runz, H, Whelan, CD, Holman, RR, Mentz, RJ, Moura, FA, Wiviott, SD, Sabatine, MS, Udler, MS, Gause-Nilsson, IA, Petrovski, S, Oscarsson, J, Nag, A, Paul, DS, Inouye, M
Format: Journal article
Language:English
Published: Nature Research 2025