Phenotypic screening and fragment-based approaches to the discovery of small-molecule bromodomain ligands.
Bromodomains are protein modules that bind to acetylated lysine residues and hence facilitate protein-protein interactions. These bromodomain-mediated interactions often play key roles in transcriptional regulation and their dysfunction is implicated in a large number of diseases. The discovery of p...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2014
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