Mechanistic insights into β-lactamase-catalysed carbapenem degradation through product characterisation
β-Lactamases are a major threat to the clinical use of carbapenems, which are often antibiotics of last resort. Despite this, the reaction outcomes and mechanisms by which β-lactamases degrade carbapenems are still not fully understood. The carbapenem bicyclic core consists of a β-lactam ring fused...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Published: |
Nature Research
2019
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