Combination therapy is superior to sequential monotherapy for the initial treatment of hypertension: A double-blind randomized controlled trial

Background--Guidelines for hypertension vary in their preference for initial combination therapy or initial monotherapy, stratified by patient profile; therefore, we compared the efficacy and tolerability of these approaches. Methods and Results--We performed a 1-year, double-blind, randomized contr...

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Main Authors: MacDonald, TM, Williams, B, Webb, DJ, Morant, S, Caulfield, M, Cruickshank, JK, Ford, I, Sever, P, Mackenzie, IS, Padmanabhan, S, McCann, GP, Salsbury, J, McInnes, G, Brown, MJ, Schumann, A, Helmy, J, Maniero, C, Burton, TJ, Quinn, U, Hobbs, L, Palmer, J, Collier, D, Markandu, N, Saxena, M, Zak, A, Enobakhare, E, Mackay, J, Thom, SA, Coughlan, C, McGinnis, AR, Findlay, E, Stanley, AG, White, C, Lacy, P, Gardiner-Hill, CJ, Nazir, S, McInnes, GT, Muir, S, McCallum, L, Melville, V, MacIntyre, IM, Brown, R, Simon, R, Soran, H, Kwok, S, Balakrishnan, K, Hobbs, R, Iles, R, Myint, KS, Cannon, J, Hood, S, Rutkowski, K, Webb, A, Martin, U, Kean, S, Wilson, R, Papworth, R
Format: Journal article
Published: American Heart Association, Inc. 2017