The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis

Objective Risk alleles for type 2 diabetes at the STARD10 locus are associated with lowered STARD10 expression in the β-cell, impaired glucose-induced insulin secretion and decreased circulating proinsulin:insulin ratios. Although likely to serve as a mediator of intracellular lipid transfer, the id...

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Bibliographic Details
Main Authors: Carrat, GR, Haythorne, E, Tomas, A, Haataja, L, Müller, A, Arvan, P, Piunti, A, Cheng, K, Huang, M, Pullen, TJ, Georgiadou, E, Stylianides, T, Amirruddin, NS, Salem, V, Distaso, W, Cakebread, A, Heesom, KJ, Lewis, PA, Hodson, DJ, Briant, LJ, Fung, ACH, Sessions, RB, Alpy, F, Kong, APS, Benke, PI, Torta, F, Keong Teo, AK, Leclerc, I, Solimena, M, Wigley, DB, Rutter, GA
Format: Journal article
Language:English
Published: Elsevier 2020

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