A synthetic peptide designed to neutralize lipopolysaccharides attenuates metaflammation and diet-induced metabolic derangements in mice

Metabolic endotoxemia has been suggested to play a role in the pathophysiology of metaflammation, insulin-resistance and ultimately type-2 diabetes mellitus (T2DM). The role of endogenous antimicrobial peptides (AMPs), such as the cathelicidin LL-37, in T2DM is unknown. We report here for the first...

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Bibliographic Details
Main Authors: Mohammad, S, Al Zoubi, S, Collotta, D, Krieg, N, Wissuwa, B, Ferreira Alves, G, Purvis, GSD, Norata, GD, Baragetti, A, Catapano, AL, Solito, E, Zechendorf, E, Schürholz, T, Correa-Vargas, W, Brandenburg, K, Coldewey, SM, Collino, M, Yaqoob, MM, Martin, L, Thiemermann, C
Format: Journal article
Language:English
Published: Frontiers Media 2021