Dynamic regulation of CD28 conformation and signaling by charged lipids and ions
CD28 provides an essential co-stimulatory signal for T cell activation and its function is critical in antitumor immunity. However, the molecular mechanism of CD28 transmembrane signaling remains elusive. Here, we find that CD28 conformation and signaling are regulated by two counteractive charge...
Հիմնական հեղինակներ: | Yang, W, Pan, W, Chen, S, Trendel, N, Jiang, S, Xiao, F, Xue, M, Wu, W, Peng, Z, Li, X, Ji, H, Liu, X, Jiang, H, Wang, H, Shen, H, Dushek, O, Li, H, Xu, C |
---|---|
Ձևաչափ: | Journal article |
Հրապարակվել է: |
Springer Nature
2017
|
Նմանատիպ նյութեր
-
Costimulation of IL-2 production through CD28 is dependent on the size of its ligand.
: Lim, H, և այլն
Հրապարակվել է: (2015) -
Perfect adaptation of CD8+ T cell responses to constant antigen input over a wide range of affinity is overcome by costimulation
: Trendel, N, և այլն
Հրապարակվել է: (2019) -
Demonstration of high-efficiency microwave heating producing record highly charged xenon ion beams with superconducting electron cyclotron resonance ion sources
: X. Wang, և այլն
Հրապարակվել է: (2024-08-01) -
Production of intense pulsed beams of highly charged ions from a superconducting electron cyclotron resonance ion source
: L. X. Li, և այլն
Հրապարակվել է: (2022-06-01) -
TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling.
: Abrahamsen, H, և այլն
Հրապարակվել է: (2004)