Dynamic regulation of CD28 conformation and signaling by charged lipids and ions
CD28 provides an essential co-stimulatory signal for T cell activation and its function is critical in antitumor immunity. However, the molecular mechanism of CD28 transmembrane signaling remains elusive. Here, we find that CD28 conformation and signaling are regulated by two counteractive charge...
| Autores principales: | , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Journal article |
| Publicado: |
Springer Nature
2017
|