Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate

Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate

The TREK subfamily of two-pore domain K+ (K2P) channels are inhibited by fluoxetine and its metabolite, norfluoxetine (NFx). Although not the principal targets of this antidepressant, TREK channel inhibition by NFx has provided important insights into the conformational changes associated with chann...

書誌詳細
主要な著者:	Proks, P, Schewe, M, Conrad, LJ, Rao, S, Rathje, K, Rödström, KEJ, Carpenter, EP, Baukrowitz, T, Tucker, SJ
フォーマット:	Journal article
言語:	English
出版事項:	Rockefeller University Press 2021

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