Pancreatic L-Glutamine Administration Protects Pig Islets from Cold Ischemic Injury and Increases Resistance toward Inflammatory Mediators

Pancreatic L-Glutamine Administration Protects Pig Islets from Cold Ischemic Injury and Increases Resistance toward Inflammatory Mediators

The isolation and transplantation of porcine islets represent a future option for the treatment of type 1 diabetic patients. Stringent product release criteria and limited availability of transgenic and specific pathogen-free pigs will essentially require processing of explanted pig pancreata in spe...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Brandhorst, H, Theisinger, B, Guenther, B, Johnson, P, Brandhorst, D
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	SAGE Publications 2016

Eitemau Tebyg

Pancreatic L-Glutamine Administration Protects Pig Islets from Cold Ischemic Injury and Increases Resistance toward Inflammatory Mediators
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Quality of isolated pig islets is improved using perfluorohexyloctane for pancreas storage in a split lobe model.
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Quality of Isolated Pig Islets is Improved Using Perfluorohexyloctane for Pancreas Storage in a Split Lobe Model
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Quality of Isolated Pig Islets is Improved Using Perfluorohexyloctane for Pancreas Storage in a Split Lobe Model
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Solubilized pancreatic extracellular matrix from juvenile pigs protects isolated human islets from hypoxia-induced damage: a viable option for clinical islet transplantation
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Heat-exposed pig islets are protected from inflammatory mediators but express proapoptotic proteins.
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Perfluorohexyloctane improves long-term storage of rat pancreata for subsequent islet isolation.
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Perlecan: An Islet Basement Membrane Protein with Protective Anti-Inflammatory Characteristics
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Pretransplant induction of HSP-70 in isolated adult pig islets decreases early islet xenograft survival.
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Prevention of early islet graft failure by selective inducible nitric oxide synthase inhibitors after pig to nude rat intraportal islet transplantation.
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Ischaemia is linked to inflammation and induction of angiogenesis in pancreatic islets.
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Long-term preservation of the pig pancreas by a one-layer method for successful islet isolation.
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Enzyme development for human islet isolation: Five decades of progress or stagnation?
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Pretransplant Induction of HSP-70 in Isolated Adult Pig Islets Decreases Early Islet Xenograft Survival
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Successful pancreas preservation by a perfluorocarbon-based one-layer method for subsequent pig islet isolation.
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Basement membrane proteins improve human islet survival in hypoxia: Implications for islet inflammation
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Can the density of native pancreatic tissue slices predict human islet isolation and purification outcome?
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Effect of etanercept concentration on human islet integrity
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Pancreas storage in oxygenated perfluorodecalin does not restore post-transplant function of isolated pig islets pre-damaged by warm ischemia.
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High-dosed nicotinamide decreases early graft failure after pig to nude rat intraportal islet transplantation.
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Prevention of intraportal islet failure by a highly selective iNOS inhibitor in the pig-to-nude rat model.
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Quantifying the effects of different neutral proteases on human islet integrity
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Degraded collagenase deteriorates islet viability.
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Adaption of neutral protease activity for islet isolation from the long-term two-layer method-stored pig pancreas.
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Induction and amelioration of environmental stress in isolated islets until transplantation
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High concentrations of Etanercept reduce human islet function and integrity
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High Concentrations of Etanercept Reduce Human Islet Function and Integrity
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Influence of collagenase loading on long-term preservation of pig pancreas by the two-layer method for subsequent islet isolation.
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Hyperthermic preconditioning protects pig islet grafts from early inflammation but enhances rejection in immunocompetent mice.
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Quantifying the Effects of Different Neutral Proteases on Human Islet Integrity
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The ischaemic preconditioning paradox and its implications for islet isolation from heart-beating and non heart-beating donors
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Anti-caspase-3 preconditioning increases proinsulin secretion and deteriorates posttransplant function of isolated human islets.
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Anti-caspase-3 preconditioning increases proinsulin secretion and deteriorates posttransplant function of isolated human islets
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Adjustment of the ratio between collagenase class II and I improves islet isolation outcome.
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A new oxygen carrier for improved long-term storage of human pancreata before islet isolation.
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