Structural/mechanistic insights into the efficacy of nonclassical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates

Structural/mechanistic insights into the efficacy of nonclassical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates

Clavulanic acid and avibactam are clinically deployed serine β-lactamase inhibitors, important as a defence against antibacterial resistance. Bicyclic boronates are recently discovered inhibitors of serine and some metallo β-lactamases. Here, we show that avibactam and a bicyclic boronate inhibit L2...

Полное описание

Библиографические подробности
Главные авторы:	Calvopiña, K, Hinchliffe, P, Brem, J, Heesom, K, Johnson, S, Cain, R, Lohans, C, Fishwick, C, Schofield, C, Spencer, J, Avison, M
Формат:	Journal article
Язык:	English
Опубликовано:	Wiley 2017

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