Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.
FIH (Factor inhibiting hypoxia-inducible factor), an asparaginyl beta-hydroxylase belonging to the super-family of 2-oxoglutarate and Fe(II)-dependent dioxygenases, catalyses hydroxylation of Asn-803 of hypoxia-inducible factor, a transcription factor that regulates the mammalian hypoxic response. O...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2004
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| _version_ | 1826297507674587136 |
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| author | Lancaster, D McDonough, M Schofield, C |
| author_facet | Lancaster, D McDonough, M Schofield, C |
| author_sort | Lancaster, D |
| collection | OXFORD |
| description | FIH (Factor inhibiting hypoxia-inducible factor), an asparaginyl beta-hydroxylase belonging to the super-family of 2-oxoglutarate and Fe(II)-dependent dioxygenases, catalyses hydroxylation of Asn-803 of hypoxia-inducible factor, a transcription factor that regulates the mammalian hypoxic response. Only one other asparaginyl beta-hydroxylase, which catalyses hydroxylation of both aspartyl and asparaginyl residues in EGF (epidermal growth factor)-like domains, has been characterized. In the light of recent crystal structures of FIH, we compare FIH with the EGFH (EGF beta-hydroxylase) and putative asparagine/asparaginyl hydroxylases. Sequence analyses imply that EGFH does not contain the HXD/E iron-binding motif characteristic of most of the 2-oxoglutarate oxygenases. |
| first_indexed | 2024-03-07T04:32:42Z |
| format | Journal article |
| id | oxford-uuid:cedf0bd7-764c-41b9-a5fa-7a3fa88e3902 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:32:42Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:cedf0bd7-764c-41b9-a5fa-7a3fa88e39022022-03-27T07:38:27ZFactor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cedf0bd7-764c-41b9-a5fa-7a3fa88e3902EnglishSymplectic Elements at Oxford2004Lancaster, DMcDonough, MSchofield, CFIH (Factor inhibiting hypoxia-inducible factor), an asparaginyl beta-hydroxylase belonging to the super-family of 2-oxoglutarate and Fe(II)-dependent dioxygenases, catalyses hydroxylation of Asn-803 of hypoxia-inducible factor, a transcription factor that regulates the mammalian hypoxic response. Only one other asparaginyl beta-hydroxylase, which catalyses hydroxylation of both aspartyl and asparaginyl residues in EGF (epidermal growth factor)-like domains, has been characterized. In the light of recent crystal structures of FIH, we compare FIH with the EGFH (EGF beta-hydroxylase) and putative asparagine/asparaginyl hydroxylases. Sequence analyses imply that EGFH does not contain the HXD/E iron-binding motif characteristic of most of the 2-oxoglutarate oxygenases. |
| spellingShingle | Lancaster, D McDonough, M Schofield, C Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases. |
| title | Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases. |
| title_full | Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases. |
| title_fullStr | Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases. |
| title_full_unstemmed | Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases. |
| title_short | Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases. |
| title_sort | factor inhibiting hypoxia inducible factor fih and other asparaginyl hydroxylases |
| work_keys_str_mv | AT lancasterd factorinhibitinghypoxiainduciblefactorfihandotherasparaginylhydroxylases AT mcdonoughm factorinhibitinghypoxiainduciblefactorfihandotherasparaginylhydroxylases AT schofieldc factorinhibitinghypoxiainduciblefactorfihandotherasparaginylhydroxylases |