Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.

Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.

FIH (Factor inhibiting hypoxia-inducible factor), an asparaginyl beta-hydroxylase belonging to the super-family of 2-oxoglutarate and Fe(II)-dependent dioxygenases, catalyses hydroxylation of Asn-803 of hypoxia-inducible factor, a transcription factor that regulates the mammalian hypoxic response. O...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Lancaster, D, McDonough, M, Schofield, C
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	2004

Antzeko izenburuak

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).
nork: Cockman, M, et al.
Argitaratua: (2006)

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803.
nork: McNeill, L, et al.
Argitaratua: (2002)

Inhibition of the oxygen-sensing asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor: a potential hypoxia response modulating strategy
nork: Wu, Y, et al.
Argitaratua: (2021)

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity.
nork: Lancaster, D, et al.
Argitaratua: (2004)

Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].
nork: Stolze, I, et al.
Argitaratua: (2004)

MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH).
nork: Webb, J, et al.
Argitaratua: (2009)

The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids.
nork: Banerji, B, et al.
Argitaratua: (2005)

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.
nork: Coleman, M, et al.
Argitaratua: (2007)

Inhibition of hypoxia inducible factor (HIF) hydroxylases
nork: Conejo-Garcia, A, et al.
Argitaratua: (2005)

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
nork: Hewitson, K, et al.
Argitaratua: (2002)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
nork: Chan, M, et al.
Argitaratua: (2016)

Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.
nork: Yang, M, et al.
Argitaratua: (2011)

Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.
nork: Cockman, M, et al.
Argitaratua: (2009)

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates.
nork: Hewitson, K, et al.
Argitaratua: (2007)

FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.
nork: Cockman, M, et al.
Argitaratua: (2009)

Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).
nork: Hewitson, K, et al.
Argitaratua: (2008)

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
nork: Chowdhury, R, et al.
Argitaratua: (2009)

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
nork: Flashman, E, et al.
Argitaratua: (2010)

Selective inhibition of factor inhibiting hypoxia-inducible factor.
nork: McDonough, M, et al.
Argitaratua: (2005)

Biochemistry of the hypoxia-inducible factor hydroxylases
nork: Fiorini, G, et al.
Argitaratua: (2024)

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor
nork: Conejo-Garcia, A, et al.
Argitaratua: (2010)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)
nork: Chowdhury, R, et al.
Argitaratua: (2011)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).
nork: Chowdhury, R, et al.
Argitaratua: (2011)

Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2
nork: Figg, WD, et al.
Argitaratua: (2023)

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity.
nork: Masson, N, et al.
Argitaratua: (2012)

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity
nork: Masson, N, et al.
Argitaratua: (2012)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
nork: Chowdhury, R, et al.
Argitaratua: (2013)

Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor.
nork: Yang, M, et al.
Argitaratua: (2013)

Inhibition studies on hypoxia-inducible factor (HIF) hydroxylases
nork: Chan, M
Argitaratua: (2014)

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
nork: McDonough, M, et al.
Argitaratua: (2006)

Fih attenuates the hypoxic tolerance of Megalobrama amblycephala by inhibiting the activity of hypoxia-inducible factor alpha (hif-α)
nork: Jun Li, et al.
Argitaratua: (2024-08-01)

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors.
nork: Tian, Y, et al.
Argitaratua: (2011)

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
nork: Hewitson, K, et al.
Argitaratua: (2007)

Studies on the inhibition of human hypoxia inducible factor (HIF) hydroxylases
nork: Yeoh, KK
Argitaratua: (2012)

Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases.
nork: Lienard, B, et al.
Argitaratua: (2008)

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.
nork: Flashman, E, et al.
Argitaratua: (2008)

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.
nork: Conejo-Garcia, A, et al.
Argitaratua: (2010)

Investigating the role of factor inhibiting HIF (FIH) in tumourigenesis
nork: Ma, J
Argitaratua: (2017)

Structural and mechanistic studies on the peroxisomal oxygenase phytanoyl-CoA 2-hydroxylase (PhyH).
nork: Schofield, C, et al.
Argitaratua: (2007)

Substrate selectivity of prolyl hydroxylases
nork: McDonough, M
Argitaratua: (2018)