Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.

BACKGROUND: Artemisinin resistance observed in Southeast Asia threatens the continued use of artemisinin-based combination therapy in endemic countries. Additionally, the diversity of chemical mode of action in the global portfolio of marketed antimalarials is extremely limited. Addressing the urgen...

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Bibliographic Details
Main Authors: Le Bihan, A, de Kanter, R, Angulo-Barturen, I, Binkert, C, Boss, C, Brun, R, Brunner, R, Buchmann, S, Burrows, J, Dechering, K, Delves, M, Ewerling, S, Ferrer, S, Fischli, C, Gamo-Benito, F, Gnädig, N, Heidmann, B, Jiménez-Díaz, M, Leroy, D, Martínez, M, Meyer, S, Moehrle, J, Ng, C, Noviyanti, R, Ruecker, A, Sanz, L, Sauerwein, R, Scheurer, C, Schleiferboeck, S, Sinden, R, Snyder, C, Straimer, J, Wirjanata, G, Marfurt, J, Price, R, Weller, T, Fischli, W, Fidock, D, Clozel, M, Wittlin, S
Format: Journal article
Language:English
Published: Public Library of Science 2016

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