Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility.

<p>The Y-chromosome is frequently lost in hematopoietic cells, representing the most common somatic mutation in men. However, the mechanisms regulating mosaic loss of chromosome-Y (mLOY), and its clinical relevance, are unknown. Using genotype array intensity data and sequence reads in 85,542...

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Bibliographic Details
Main Authors:	Wright, D, Day, F, Kerrison, N, Zink, F, Cardona, A, Sulem, P, Thompson, D, Sigurjonsdottir, S, Gudbjartsson, D, Helgason, A, Chapman, J, Jackson, S, Langenberg, C, Wareham, N, Scott, R, Thorsteindottir, U, Ong, K, Stefansson, K, Perry, J
Format:	Journal article
Language:	English
Published:	Nature Publishing Group 2017

Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility.

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